NP-MRD: Showing NP-Card for 2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid (NP0330721)

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Record Information

Version

1.0

Created at

2022-09-12 16:20:41 UTC

Updated at

2022-09-12 16:20:41 UTC

NP-MRD ID

NP0330721

Secondary Accession Numbers

None

Natural Product Identification

Common Name

2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid

Description

2-(1-Carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,8,9,10,10a,12,12a-hexadecahydrochrysene-1,9-dicarboxylic acid belongs to the class of organic compounds known as hydroxysteroids. Hydroxysteroids are compounds containing an steroid backbone, with at least one hydrogen substituted by a hydroxyl group. 2-(1-Carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,8,9,10,10a,12,12a-hexadecahydrochrysene-1,9-dicarboxylic acid is a weakly acidic compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004231523132D          

 35 38  0  0  0  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1533004231523132D          

 35 38  0  0  0  0            999 V2000
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    0.6443   -1.1874    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0015   -2.8323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5415   -3.4559    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2715   -2.0527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7 23  1  0  0  0  0
 12 23  1  0  0  0  0
 23 24  1  0  0  0  0
 15 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
  9 28  1  0  0  0  0
  4 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
  2 33  1  0  0  0  0
 33 34  2  0  0  0  0
 33 35  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0330721

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)(C1CCC2(C)C(CC=C3C4CC(C)(CCC4(C)CCC23C)C(O)=O)C1(C)C(O)=O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C29H44O6/c1-24(2,21(30)31)19-10-11-28(6)20(29(19,7)23(34)35)9-8-17-18-16-26(4,22(32)33)13-12-25(18,3)14-15-27(17,28)5/h8,18-20H,9-16H2,1-7H3,(H,30,31)(H,32,33)(H,34,35)

> <INCHI_KEY>
KOBANWAAKSSVAC-UHFFFAOYSA-N

> <FORMULA>
C29H44O6

> <MOLECULAR_WEIGHT>
488.665

> <EXACT_MASS>
488.313789137

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
79

> <JCHEM_AVERAGE_POLARIZABILITY>
55.2053764328665

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,8,9,10,10a,12,12a-hexadecahydrochrysene-1,9-dicarboxylic acid

> <ALOGPS_LOGP>
4.71

> <JCHEM_LOGP>
6.228186936

> <ALOGPS_LOGS>
-5.48

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-3

> <JCHEM_PKA>
4.566695746044053

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.062586117191825

> <JCHEM_POLAR_SURFACE_AREA>
111.89999999999999

> <JCHEM_REFRACTIVITY>
132.74460000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.63e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2H-chrysene-1,9-dicarboxylic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 23-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-APR-15         0                                  
HETATM    1  C   UNK     0      -0.066  -4.066   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.357  -5.578   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -0.648  -7.090   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.155  -5.869   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.659  -7.324   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.171  -7.615   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.180  -6.451   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.684  -7.906   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.676  -4.996   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.684  -3.832   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.196  -4.123   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       6.700  -5.578   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.212  -5.869   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       9.220  -4.705   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      10.733  -4.996   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      10.757  -3.456   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      11.237  -6.451   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      10.229  -7.615   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       8.716  -7.324   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       9.220  -8.779   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       7.708  -8.488   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       6.196  -8.197   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       5.692  -6.742   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       5.560  -8.276   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      12.253  -4.752   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0      12.802  -3.313   0.000  0.00  0.00           O+0
HETATM   27  O   UNK     0      13.225  -5.947   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       2.163  -4.705   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       1.035  -3.657   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       2.401  -3.183   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       3.838  -2.629   0.000  0.00  0.00           O+0
HETATM   32  O   UNK     0       1.203  -2.216   0.000  0.00  0.00           O+0
HETATM   33  C   UNK     0      -1.869  -5.287   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0      -2.878  -6.451   0.000  0.00  0.00           O+0
HETATM   35  O   UNK     0      -2.373  -3.832   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    4   33                                             
CONECT    3    2                                                            
CONECT    4    2    5   28                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8    9   23                                             
CONECT    8    7                                                            
CONECT    9    7   10   28                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13   23                                                  
CONECT   13   12   14   19                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16   17   25                                             
CONECT   16   15                                                            
CONECT   17   15   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   13   20   21                                             
CONECT   20   19                                                            
CONECT   21   19   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22    7   12   24                                             
CONECT   24   23                                                            
CONECT   25   15   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25                                                            
CONECT   28    9    4   29   30                                             
CONECT   29   28                                                            
CONECT   30   28   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30                                                            
CONECT   33    2   34   35                                                  
CONECT   34   33                                                            
CONECT   35   33                                                            
MASTER        0    0    0    0    0    0    0    0   35    0   76    0
END

View in JSmol

Synonyms

Value	Source
2-(1-Carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,8,9,10,10a,12,12a-hexadecahydrochrysene-1,9-dicarboxylate	Generator

Chemical Formula

C₂₉H₄₄O₆

Average Mass

488.6650 Da

Monoisotopic Mass

488.31379 Da

IUPAC Name

2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,8,9,10,10a,12,12a-hexadecahydrochrysene-1,9-dicarboxylic acid

Traditional Name

2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2H-chrysene-1,9-dicarboxylic acid

CAS Registry Number

Not Available

SMILES

CC(C)(C1CCC2(C)C(CC=C3C4CC(C)(CCC4(C)CCC23C)C(O)=O)C1(C)C(O)=O)C(O)=O

InChI Identifier

InChI=1S/C29H44O6/c1-24(2,21(30)31)19-10-11-28(6)20(29(19,7)23(34)35)9-8-17-18-16-26(4,22(32)33)13-12-25(18,3)14-15-27(17,28)5/h8,18-20H,9-16H2,1-7H3,(H,30,31)(H,32,33)(H,34,35)

InChI Key

KOBANWAAKSSVAC-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as hydroxysteroids. Hydroxysteroids are compounds containing an steroid backbone, with at least one hydrogen substituted by a hydroxyl group.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Hydroxysteroids

Direct Parent

Hydroxysteroids

Alternative Parents

Substituents

20-hydroxysteroid
17-carboxy steroid
Steroid acid
Diterpenoid
Hydroxysteroid
15-hydroxysteroid
Tricarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.71	ALOGPS
logP	6.23	ChemAxon
logS	-5.5	ALOGPS
pKa (Strongest Acidic)	4.06	ChemAxon
Physiological Charge	-3	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	111.9 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	132.74 m³·mol⁻¹	ChemAxon
Polarizability	55.21 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

76008043

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid (NP0330721)

MOL for NP0330721 (2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid)

3D MOL for NP0330721 (2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid)

3D SDF for NP0330721 (2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid)

3D-SDF for NP0330721 (2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid)

PDB for NP0330721 (2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid)

3D PDB for NP0330721 (2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid)

SMILES for NP0330721 (2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid)

INCHI for NP0330721 (2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid)

Structure for NP0330721 (2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid)

3D Structure for NP0330721 (2-(1-carboxy-1-methylethyl)-1,4a,4b,6a,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2h-chrysene-1,9-dicarboxylic acid)