NP-MRD: Showing NP-Card for n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid (NP0330281)

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Record Information

Version

1.0

Created at

2022-09-12 15:28:35 UTC

Updated at

2022-09-12 15:28:35 UTC

NP-MRD ID

NP0330281

Secondary Accession Numbers

None

Natural Product Identification

Common Name

n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid

Description

N-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid is found in Grangea maderaspatana. N-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004241506082D          

 39 42  0  0  0  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1533004241506082D          

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  8 13  1  0  0  0  0
  6 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 17 22  1  0  0  0  0
  2 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 25 30  1  0  0  0  0
 23 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  2  0  0  0  0
 35 36  1  0  0  0  0
 36 37  2  0  0  0  0
 37 38  1  0  0  0  0
 38 39  2  0  0  0  0
 34 39  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0330281

> <DATABASE_NAME>
NP-MRD

> <SMILES>
O=C(OC(=O)C(CC1=CC=CC=C1)NC(=O)C1=CC=CC=C1)C(CC1=CC=CC=C1)NC(=O)C1=CC=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C32H28N2O5/c35-29(25-17-9-3-10-18-25)33-27(21-23-13-5-1-6-14-23)31(37)39-32(38)28(22-24-15-7-2-8-16-24)34-30(36)26-19-11-4-12-20-26/h1-20,27-28H,21-22H2,(H,33,35)(H,34,36)

> <INCHI_KEY>
ZNIWDDMJHDNRAC-UHFFFAOYSA-N

> <FORMULA>
C32H28N2O5

> <MOLECULAR_WEIGHT>
520.585

> <EXACT_MASS>
520.19982201

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
67

> <JCHEM_AVERAGE_POLARIZABILITY>
55.597275807334114

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
3-phenyl-2-(phenylformamido)propanoyl 3-phenyl-2-(phenylformamido)propanoate

> <ALOGPS_LOGP>
4.65

> <JCHEM_LOGP>
5.635444199

> <ALOGPS_LOGS>
-6.58

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.322111076307646

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.72005104172618

> <JCHEM_PKA_STRONGEST_BASIC>
-1.0433736296636766

> <JCHEM_POLAR_SURFACE_AREA>
101.57

> <JCHEM_REFRACTIVITY>
147.25579999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
12

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.36e-04 g/l

> <JCHEM_TRADITIONAL_IUPAC>
3-phenyl-2-(phenylformamido)propanoyl 3-phenyl-2-(phenylformamido)propanoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-APR-15         0                                  
HETATM    1  O   UNK     0      16.920  -9.141   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0      16.685  -7.619   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0      15.250  -7.061   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0      14.049  -8.026   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0      14.284  -9.548   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0      12.614  -7.468   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      11.920  -6.093   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      12.764  -4.805   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      12.070  -3.430   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      12.914  -2.142   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      14.452  -2.228   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      15.145  -3.603   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      14.302  -4.892   0.000  0.00  0.00           C+0
HETATM   14  N   UNK     0      11.413  -8.432   0.000  0.00  0.00           N+0
HETATM   15  C   UNK     0       9.978  -7.875   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       9.743  -6.353   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       8.777  -8.839   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       9.012 -10.361   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       7.811 -11.326   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       6.376 -10.768   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       6.141  -9.246   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       7.341  -8.282   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      17.886  -6.654   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      18.591  -5.285   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      17.757  -3.990   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      16.219  -4.065   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      15.385  -2.770   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      16.090  -1.400   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      17.628  -1.326   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      18.462  -2.621   0.000  0.00  0.00           C+0
HETATM   31  N   UNK     0      18.720  -7.949   0.000  0.00  0.00           N+0
HETATM   32  C   UNK     0      20.258  -7.875   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0      20.962  -6.505   0.000  0.00  0.00           O+0
HETATM   34  C   UNK     0      21.091  -9.170   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0      22.630  -9.095   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0      23.463 -10.390   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0      22.759 -11.759   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0      21.221 -11.834   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0      20.387 -10.539   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   23                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7   14                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   13                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12    8                                                       
CONECT   14    6   15                                                       
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18   22                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   17                                                       
CONECT   23    2   24   31                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26   30                                                  
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   25                                                       
CONECT   31   23   32                                                       
CONECT   32   31   33   34                                                  
CONECT   33   32                                                            
CONECT   34   32   35   39                                                  
CONECT   35   34   36                                                       
CONECT   36   35   37                                                       
CONECT   37   36   38                                                       
CONECT   38   37   39                                                       
CONECT   39   38   34                                                       
MASTER        0    0    0    0    0    0    0    0   39    0   84    0
END

View in JSmol

Synonyms

Value	Source
N-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidate	Generator

Chemical Formula

C₃₂H₂₈N₂O₅

Average Mass

520.5850 Da

Monoisotopic Mass

520.19982 Da

IUPAC Name

3-phenyl-2-(phenylformamido)propanoyl 3-phenyl-2-(phenylformamido)propanoate

Traditional Name

3-phenyl-2-(phenylformamido)propanoyl 3-phenyl-2-(phenylformamido)propanoate

CAS Registry Number

Not Available

SMILES

O=C(OC(=O)C(CC1=CC=CC=C1)NC(=O)C1=CC=CC=C1)C(CC1=CC=CC=C1)NC(=O)C1=CC=CC=C1

InChI Identifier

InChI=1S/C32H28N2O5/c35-29(25-17-9-3-10-18-25)33-27(21-23-13-5-1-6-14-23)31(37)39-32(38)28(22-24-15-7-2-8-16-24)34-30(36)26-19-11-4-12-20-26/h1-20,27-28H,21-22H2,(H,33,35)(H,34,36)

InChI Key

ZNIWDDMJHDNRAC-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Grangea maderaspatana	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Phenylalanine and derivatives

Alternative Parents

Substituents

Phenylalanine or derivatives
N-acyl-alpha amino acid or derivatives
Amphetamine or derivatives
Monocyclic benzene moiety
Dicarboxylic acid or derivatives
Benzenoid
Carboxylic acid anhydride
Carboximidic acid
Carboximidic acid derivative
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Organic nitrogen compound
Organonitrogen compound
Organooxygen compound
Organic oxygen compound
Carbonyl group
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.65	ALOGPS
logP	5.64	ChemAxon
logS	-6.6	ALOGPS
pKa (Strongest Acidic)	14.72	ChemAxon
pKa (Strongest Basic)	-1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	101.57 Å²	ChemAxon
Rotatable Bond Count	12	ChemAxon
Refractivity	147.26 m³·mol⁻¹	ChemAxon
Polarizability	55.6 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid (NP0330281)

MOL for NP0330281 (n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid)

3D MOL for NP0330281 (n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid)

3D SDF for NP0330281 (n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid)

3D-SDF for NP0330281 (n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid)

PDB for NP0330281 (n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid)

3D PDB for NP0330281 (n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid)

SMILES for NP0330281 (n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid)

INCHI for NP0330281 (n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid)

Structure for NP0330281 (n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid)

3D Structure for NP0330281 (n-{1-[(2-{[hydroxy(phenyl)methylidene]amino}-3-phenylpropanoyl)oxy]-1-oxo-3-phenylpropan-2-yl}benzenecarboximidic acid)