Record Information |
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Version | 1.0 |
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Created at | 2022-09-07 01:46:22 UTC |
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Updated at | 2022-09-07 01:46:22 UTC |
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NP-MRD ID | NP0241639 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | (1s,10r)-10,13-bis[(2s)-butan-2-yl]-12,14-dihydroxy-11-oxo-6-[2,3,4'-tris(acetyloxy)-5,6-dihydroxy-[1,1'-biphenyl]-4-yl]-2,9-dioxa-1,12-diazatricyclo[8.4.0.0³,⁸]tetradeca-3,5,7,13-tetraen-1-ium-1-olate |
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Description | Sarcodonin belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond. (1s,10r)-10,13-bis[(2s)-butan-2-yl]-12,14-dihydroxy-11-oxo-6-[2,3,4'-tris(acetyloxy)-5,6-dihydroxy-[1,1'-biphenyl]-4-yl]-2,9-dioxa-1,12-diazatricyclo[8.4.0.0³,⁸]tetradeca-3,5,7,13-tetraen-1-ium-1-olate is found in Sarcodon leucopus. It was first documented in 2011 (PMID: 21250718). Based on a literature review a significant number of articles have been published on Sarcodonin (PMID: 29653489) (PMID: 23586893) (PMID: 23577748) (PMID: 35597110). |
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Structure | CC[C@H](C)C1=C(O)[N@+]2([O-])OC3=CC=C(C=C3O[C@]2([C@@H](C)CC)C(=O)N1O)C1=C(O)C(O)=C(C2=CC=C(OC(C)=O)C=C2)C(OC(C)=O)=C1OC(C)=O InChI=1S/C36H38N2O14/c1-8-17(3)29-34(44)38(47)36(18(4)9-2,35(45)37(29)46)51-26-16-23(12-15-25(26)52-38)28-31(43)30(42)27(22-10-13-24(14-11-22)48-19(5)39)32(49-20(6)40)33(28)50-21(7)41/h10-18,42-44,46H,8-9H2,1-7H3/t17-,18-,36+,38-/m0/s1 |
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Synonyms | Value | Source |
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Sarcodonin m | MeSH |
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Chemical Formula | C36H38N2O14 |
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Average Mass | 722.7000 Da |
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Monoisotopic Mass | 722.23230 Da |
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IUPAC Name | Not Available |
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Traditional Name | Not Available |
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CAS Registry Number | Not Available |
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SMILES | CC[C@H](C)C1=C(O)[N@+]2([O-])OC3=CC=C(C=C3O[C@]2([C@@H](C)CC)C(=O)N1O)C1=C(O)C(O)=C(C2=CC=C(OC(C)=O)C=C2)C(OC(C)=O)=C1OC(C)=O |
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InChI Identifier | InChI=1S/C36H38N2O14/c1-8-17(3)29-34(44)38(47)36(18(4)9-2,35(45)37(29)46)51-26-16-23(12-15-25(26)52-38)28-31(43)30(42)27(22-10-13-24(14-11-22)48-19(5)39)32(49-20(6)40)33(28)50-21(7)41/h10-18,42-44,46H,8-9H2,1-7H3/t17-,18-,36+,38-/m0/s1 |
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InChI Key | ULLCSSTZNGODKE-KRNPDVCNSA-N |
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Experimental Spectra |
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| Not Available | Predicted Spectra |
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| Spectrum Type | Description | Depositor ID | Depositor Organization | Depositor | Deposition Date | View |
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1D NMR | 13C NMR Spectrum (1D, 25 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 100 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 252 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 50 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 200 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 75 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 300 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 101 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 400 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 126 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 500 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 151 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 600 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 176 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 700 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 201 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 800 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 226 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 900 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Chemical Shift Submissions |
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| Not Available | Species |
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Species of Origin | |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond. |
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Kingdom | Organic compounds |
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Super Class | Benzenoids |
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Class | Benzene and substituted derivatives |
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Sub Class | Biphenyls and derivatives |
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Direct Parent | Biphenyls and derivatives |
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Alternative Parents | |
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Substituents | - Biphenyl
- Alpha-amino acid or derivatives
- Phenol ester
- Tricarboxylic acid or derivatives
- Phenoxy compound
- Catechol
- Phenol
- Carboxylic acid ester
- Hydroxamic acid
- Organoheterocyclic compound
- Oxacycle
- Alkanolamine
- Carboxylic acid derivative
- N-organohydroxylamine
- Azacycle
- Organic zwitterion
- Hydrocarbon derivative
- Organic oxide
- Organooxygen compound
- Organonitrogen compound
- Organic nitrogen compound
- Organopnictogen compound
- Carbonyl group
- Organic oxygen compound
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | Not Available |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Cao CY, Zhang CC, Shi XW, Li D, Cao W, Yin X, Gao JM: Sarcodonin G Derivatives Exhibit Distinctive Effects on Neurite Outgrowth by Modulating NGF Signaling in PC12 Cells. ACS Chem Neurosci. 2018 Jul 18;9(7):1607-1615. doi: 10.1021/acschemneuro.7b00488. Epub 2018 Apr 27. [PubMed:29653489 ]
- Masubuti H, Endo Y, Araya H, Uekusa H, Fujimoto Y: Establishment of benzodioxazine core structure for sarcodonin class of natural products by X-ray analysis. Org Lett. 2013 May 3;15(9):2076-9. doi: 10.1021/ol400595k. Epub 2013 Apr 15. [PubMed:23586893 ]
- Usui I, Lin DW, Masuda T, Baran PS: Convergent synthesis and structural confirmation of phellodonin and sarcodonin epsilon. Org Lett. 2013 May 3;15(9):2080-3. doi: 10.1021/ol400709f. Epub 2013 Apr 11. [PubMed:23577748 ]
- Lin DW, Masuda T, Biskup MB, Nelson JD, Baran PS: Synthesis-guided structure revision of the sarcodonin, sarcoviolin, and hydnellin natural product family. J Org Chem. 2011 Feb 18;76(4):1013-30. doi: 10.1021/jo102228j. Epub 2011 Jan 20. [PubMed:21250718 ]
- Cao CY, Yang YX, Xie Z, Chen X, Shi XW, Yin X, Gao JM: Derivatives of sarcodonin A isolated from Sarcodon scabrosus reversed LPS-induced M1 polarization in microglia through MAPK/NF-kappaB pathway. Bioorg Chem. 2022 Aug;125:105854. doi: 10.1016/j.bioorg.2022.105854. Epub 2022 May 9. [PubMed:35597110 ]
- LOTUS database [Link]
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