NP-MRD: Showing NP-Card for {13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate (NP0207949)

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Record Information

Version

1.0

Created at

2022-09-05 04:45:29 UTC

Updated at

2022-09-05 04:45:29 UTC

NP-MRD ID

NP0207949

Secondary Accession Numbers

None

Natural Product Identification

Common Name

{13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate

Description

{11-Hydroxy-1,10,14,18-tetramethyl-8-oxo-7-oxapentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]Henicos-5(9)-en-18-yl}methyl acetate belongs to the class of organic compounds known as scalarane sesterterpenoids. These are sesterterpenoids with a structure based on the scalarane backbone. Scalarane is a tetracyclic compound, which is similar the homoandrostane with five methyl groups at the 4-, 4-, 8-, 17-, 17a-positions. {13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate is found in Hyrtios erectus. {11-Hydroxy-1,10,14,18-tetramethyl-8-oxo-7-oxapentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]Henicos-5(9)-en-18-yl}methyl acetate is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004151518102D          

 32 36  0  0  0  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1533004151518102D          

 32 36  0  0  0  0            999 V2000
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 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 11 32  1  0  0  0  0
 16 32  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0207949

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(=O)OCC1(C)CCCC2(C)C1CCC1(C)C3CCC4=C(C(=O)OC4)C3(C)C(O)CC21

> <INCHI_IDENTIFIER>
InChI=1S/C27H40O5/c1-16(28)32-15-24(2)10-6-11-25(3)18(24)9-12-26(4)19-8-7-17-14-31-23(30)22(17)27(19,5)21(29)13-20(25)26/h18-21,29H,6-15H2,1-5H3

> <INCHI_KEY>
HBZMFBSNLZLYMN-UHFFFAOYSA-N

> <FORMULA>
C27H40O5

> <MOLECULAR_WEIGHT>
444.612

> <EXACT_MASS>
444.287574388

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
72

> <JCHEM_AVERAGE_POLARIZABILITY>
50.734563427540344

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
{11-hydroxy-1,10,14,18-tetramethyl-8-oxo-7-oxapentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]henicos-5(9)-en-18-yl}methyl acetate

> <ALOGPS_LOGP>
4.00

> <JCHEM_LOGP>
4.016038399999999

> <ALOGPS_LOGS>
-5.07

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.632375942774818

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.280981240831014

> <JCHEM_PKA_STRONGEST_BASIC>
-2.9704488444271417

> <JCHEM_POLAR_SURFACE_AREA>
72.83000000000001

> <JCHEM_REFRACTIVITY>
121.66799999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.82e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
{11-hydroxy-1,10,14,18-tetramethyl-8-oxo-7-oxapentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]henicos-5(9)-en-18-yl}methyl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-APR-15         0                                  
HETATM    1  C   UNK     0      -3.349  -5.661   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -2.155  -4.689   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0      -2.399  -3.169   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0      -0.716  -5.238   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       0.479  -4.266   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.918  -4.815   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       2.208  -3.302   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       1.128  -6.137   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       1.877  -7.482   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.417  -7.505   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.207  -6.183   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       4.957  -7.529   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       3.458  -4.838   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       4.248  -3.516   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       5.788  -3.540   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       6.537  -4.885   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       7.327  -3.563   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       8.077  -4.908   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       8.867  -3.587   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      10.407  -3.610   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      11.157  -4.955   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      10.366  -6.277   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      11.379  -7.437   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      11.036  -8.938   0.000  0.00  0.00           O+0
HETATM   25  O   UNK     0      12.796  -6.832   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0      12.658  -5.298   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       8.827  -6.254   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       9.576  -7.599   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       8.036  -7.575   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0       8.786  -8.921   0.000  0.00  0.00           O+0
HETATM   31  C   UNK     0       6.497  -7.552   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       5.747  -6.207   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7    8   13                                             
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12   13   32                                             
CONECT   12   11                                                            
CONECT   13   11    6   14                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17   18   32                                             
CONECT   17   16                                                            
CONECT   18   16   19   27                                                  
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22   26                                                  
CONECT   22   21   23   27                                                  
CONECT   23   22   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23   26                                                       
CONECT   26   25   21                                                       
CONECT   27   22   18   28   29                                             
CONECT   28   27                                                            
CONECT   29   27   30   31                                                  
CONECT   30   29                                                            
CONECT   31   29   32                                                       
CONECT   32   31   11   16                                                  
MASTER        0    0    0    0    0    0    0    0   32    0   72    0
END

View in JSmol

Synonyms

Value	Source
{11-hydroxy-1,10,14,18-tetramethyl-8-oxo-7-oxapentacyclo[11.8.0.0,.0,.0,]henicos-5(9)-en-18-yl}methyl acetic acid	Generator
{11-hydroxy-1,10,14,18-tetramethyl-8-oxo-7-oxapentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]henicos-5(9)-en-18-yl}methyl acetic acid	Generator

Chemical Formula

C₂₇H₄₀O₅

Average Mass

444.6120 Da

Monoisotopic Mass

444.28757 Da

IUPAC Name

{11-hydroxy-1,10,14,18-tetramethyl-8-oxo-7-oxapentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]henicos-5(9)-en-18-yl}methyl acetate

Traditional Name

{11-hydroxy-1,10,14,18-tetramethyl-8-oxo-7-oxapentacyclo[11.8.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁹]henicos-5(9)-en-18-yl}methyl acetate

CAS Registry Number

Not Available

SMILES

CC(=O)OCC1(C)CCCC2(C)C1CCC1(C)C3CCC4=C(C(=O)OC4)C3(C)C(O)CC21

InChI Identifier

InChI=1S/C27H40O5/c1-16(28)32-15-24(2)10-6-11-25(3)18(24)9-12-26(4)19-8-7-17-14-31-23(30)22(17)27(19,5)21(29)13-20(25)26/h18-21,29H,6-15H2,1-5H3

InChI Key

HBZMFBSNLZLYMN-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Hyrtios erectus	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as scalarane sesterterpenoids. These are sesterterpenoids with a structure based on the scalarane backbone. Scalarane is a tetracyclic compound, which is similar the homoandrostane with five methyl groups at the 4-, 4-, 8-, 17-, 17a-positions.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesterterpenoids

Direct Parent

Scalarane sesterterpenoids

Alternative Parents

Substituents

Scalarane sesterterpenoid
Steroid lactone
Hydroxysteroid
7-hydroxysteroid
16-oxasteroid
Steroid
2-furanone
Dicarboxylic acid or derivatives
Cyclic alcohol
Dihydrofuran
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Lactone
Carboxylic acid ester
Secondary alcohol
Oxacycle
Carboxylic acid derivative
Organoheterocyclic compound
Organooxygen compound
Hydrocarbon derivative
Organic oxide
Alcohol
Organic oxygen compound
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4	ALOGPS
logP	4.02	ChemAxon
logS	-5.1	ALOGPS
pKa (Strongest Acidic)	13.28	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	72.83 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	121.67 m³·mol⁻¹	ChemAxon
Polarizability	50.73 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

73090098

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for {13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate (NP0207949)

MOL for NP0207949 ({13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate)

3D MOL for NP0207949 ({13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate)

3D SDF for NP0207949 ({13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate)

3D-SDF for NP0207949 ({13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate)

PDB for NP0207949 ({13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate)

3D PDB for NP0207949 ({13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate)

SMILES for NP0207949 ({13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate)

INCHI for NP0207949 ({13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate)

Structure for NP0207949 ({13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate)

3D Structure for NP0207949 ({13-hydroxy-5b,8,11a,13a-tetramethyl-1-oxo-3h,4h,5h,5ah,6h,7h,7ah,9h,10h,11h,11bh,12h,13h-chryseno[1,2-c]furan-8-yl}methyl acetate)