NP-MRD: Showing NP-Card for Polyphyllin C (NP0140869)

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Record Information

Version

1.0

Created at

2022-06-29 21:55:57 UTC

Updated at

2022-06-29 21:55:57 UTC

NP-MRD ID

NP0140869

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Polyphyllin C

Description

Polyphyllin C belongs to the class of organic compounds known as steroidal saponins. These are saponins in which the aglycone moiety is a steroid. The steroidal aglycone is usually a spirostane, furostane, spirosolane, solanidane, or curcubitacin derivative. Polyphyllin C is found in Paris polyphylla and Tacca chantrieri. It was first documented in 2020 (PMID: 32281356). Based on a literature review a significant number of articles have been published on Polyphyllin C (PMID: 35463067) (PMID: 35027659) (PMID: 35699751) (PMID: 35237147) (PMID: 35116689) (PMID: 33875166).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652306292223552D          

 51 58  0  0  1  0            999 V2000
    8.5863    0.1450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
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  8 10  1  0  0  0  0
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  6 49  1  1  0  0  0
  5 50  1  0  0  0  0
 50 51  1  0  0  0  0
  2 51  1  0  0  0  0
M  END

     RDKit          3D

113120  0  0  0  0  0  0  0  0999 V2000
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 29 30  1  0
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 43104  1  0
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 15 65  1  1
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 42103  1  1
 41101  1  0
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 39 96  1  0
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 39 98  1  0
 13 64  1  1
  9 60  1  1
 10 61  1  0
 10 62  1  0
 11 63  1  0
  7 58  1  1
  8 59  1  0
  6 57  1  6
  4 56  1  6
  2 55  1  1
  1 52  1  0
  1 53  1  0
  1 54  1  0
 50112  1  1
 51113  1  0
 48110  1  6
 49111  1  0
 46108  1  1
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 44106  1  6
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 29 81  1  0
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 32 88  1  0
 33 89  1  0
 33 90  1  0
M  END


  Mrv1652306292223552D          

 51 58  0  0  1  0            999 V2000
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    4.9582    1.1592    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
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    4.2253    1.5379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6386    0.9580    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
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    3.5556   -0.4686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7320   -0.4206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3617    0.3166    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8150    1.0059    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4447    1.7431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6211    1.7911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1678    1.1018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5381    0.3646    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.0848   -0.3247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2611   -0.2768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1091    0.4604    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3442    1.1497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9327    0.5084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3030    1.2456    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1266    1.2936    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.4969    2.0308    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.0436    2.7201    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.2200    2.6721    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.8497    1.9349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7667    3.3614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0569    3.3135    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4139    3.4573    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3205    2.0787    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6908    2.8160    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.5144    2.8639    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.8847    3.6011    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.4314    4.2904    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.6078    4.2425    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.2375    3.5053    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1544    4.9318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8017    5.0277    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7083    3.6491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9677    2.1746    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5800    0.6043    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9084   -0.3727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4542   -0.4738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6817   -0.8493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6670    1.1844    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4811    1.0506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  7  6  1  6  0  0  0
  7  8  1  0  0  0  0
  8  9  1  6  0  0  0
  5  9  1  6  0  0  0
  8 10  1  0  0  0  0
 11 10  1  6  0  0  0
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  7 12  1  0  0  0  0
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 13 14  1  0  0  0  0
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 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
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 26 25  1  1  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
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 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 30 32  1  1  0  0  0
 32 33  1  0  0  0  0
 29 34  1  6  0  0  0
 28 35  1  1  0  0  0
 36 35  1  1  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 36 41  1  0  0  0  0
 40 42  1  6  0  0  0
 39 43  1  1  0  0  0
 38 44  1  6  0  0  0
 37 45  1  6  0  0  0
 27 46  1  6  0  0  0
 20 47  1  6  0  0  0
 12 48  1  6  0  0  0
  6 49  1  1  0  0  0
  5 50  1  0  0  0  0
 50 51  1  0  0  0  0
  2 51  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0140869

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H]2O)O[C@]11CC[C@@H](C)CO1

> <INCHI_IDENTIFIER>
InChI=1S/C39H62O12/c1-18-8-13-39(46-17-18)19(2)28-26(51-39)15-25-23-7-6-21-14-22(9-11-37(21,4)24(23)10-12-38(25,28)5)48-36-33(45)34(30(42)27(16-40)49-36)50-35-32(44)31(43)29(41)20(3)47-35/h6,18-20,22-36,40-45H,7-17H2,1-5H3/t18-,19+,20+,22+,23-,24+,25+,26+,27-,28+,29+,30-,31-,32-,33-,34+,35+,36-,37+,38+,39-/m1/s1

> <INCHI_KEY>
OJCPWEBMROBPTK-GTCMQMDYSA-N

> <FORMULA>
C39H62O12

> <MOLECULAR_WEIGHT>
722.913

> <EXACT_MASS>
722.424127436

$$$$

HEADER    PROTEIN                                 29-JUN-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   29-JUN-22         0                                  
HETATM    1  C   UNK     0      16.028   0.271   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      14.508   0.520   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      13.532  -0.671   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      12.013  -0.421   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      11.469   1.020   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.374  -0.063   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       9.006   0.644   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       9.255   2.164   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0      10.778   2.396   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       7.887   2.871   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.792   1.788   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       7.483   0.412   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       6.637  -0.875   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       5.100  -0.785   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.408   0.591   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.255   1.878   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.563   3.254   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       3.026   3.343   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.180   2.057   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       2.871   0.681   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       2.025  -0.606   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       0.487  -0.517   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      -0.204   0.859   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       0.642   2.146   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0      -1.741   0.949   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0      -2.432   2.325   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -3.970   2.415   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      -4.661   3.791   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      -3.815   5.077   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      -2.277   4.988   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0      -1.586   3.612   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0      -1.431   6.275   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0       0.106   6.185   0.000  0.00  0.00           O+0
HETATM   34  O   UNK     0      -4.506   6.454   0.000  0.00  0.00           O+0
HETATM   35  O   UNK     0      -6.198   3.880   0.000  0.00  0.00           O+0
HETATM   36  C   UNK     0      -6.890   5.256   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0      -8.427   5.346   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0      -9.118   6.722   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0      -8.272   8.009   0.000  0.00  0.00           C+0
HETATM   40  C   UNK     0      -6.735   7.919   0.000  0.00  0.00           C+0
HETATM   41  O   UNK     0      -6.043   6.543   0.000  0.00  0.00           O+0
HETATM   42  C   UNK     0      -5.888   9.206   0.000  0.00  0.00           C+0
HETATM   43  O   UNK     0      -8.963   9.385   0.000  0.00  0.00           O+0
HETATM   44  O   UNK     0     -10.655   6.812   0.000  0.00  0.00           O+0
HETATM   45  O   UNK     0      -9.273   4.059   0.000  0.00  0.00           O+0
HETATM   46  O   UNK     0      -4.816   1.128   0.000  0.00  0.00           O+0
HETATM   47  C   UNK     0       3.562  -0.696   0.000  0.00  0.00           C+0
HETATM   48  C   UNK     0       8.315  -0.884   0.000  0.00  0.00           C+0
HETATM   49  C   UNK     0      10.606  -1.585   0.000  0.00  0.00           C+0
HETATM   50  O   UNK     0      12.445   2.211   0.000  0.00  0.00           O+0
HETATM   51  C   UNK     0      13.965   1.961   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   51                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    9   50                                             
CONECT    6    5    7   49                                                  
CONECT    7    6    8   12                                                  
CONECT    8    7    9   10                                                  
CONECT    9    8    5                                                       
CONECT   10    8   11                                                       
CONECT   11   10   12   16                                                  
CONECT   12   11    7   13   48                                             
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16   20                                                  
CONECT   16   15   11   17                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20   24                                                  
CONECT   20   19   15   21   47                                             
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24   25                                                  
CONECT   24   23   19                                                       
CONECT   25   23   26                                                       
CONECT   26   25   27   31                                                  
CONECT   27   26   28   46                                                  
CONECT   28   27   29   35                                                  
CONECT   29   28   30   34                                                  
CONECT   30   29   31   32                                                  
CONECT   31   30   26                                                       
CONECT   32   30   33                                                       
CONECT   33   32                                                            
CONECT   34   29                                                            
CONECT   35   28   36                                                       
CONECT   36   35   37   41                                                  
CONECT   37   36   38   45                                                  
CONECT   38   37   39   44                                                  
CONECT   39   38   40   43                                                  
CONECT   40   39   41   42                                                  
CONECT   41   40   36                                                       
CONECT   42   40                                                            
CONECT   43   39                                                            
CONECT   44   38                                                            
CONECT   45   37                                                            
CONECT   46   27                                                            
CONECT   47   20                                                            
CONECT   48   12                                                            
CONECT   49    6                                                            
CONECT   50    5   51                                                       
CONECT   51   50    2                                                       
MASTER        0    0    0    0    0    0    0    0   51    0  116    0
END

View in JSmol

Synonyms

Value	Source
Polyphillin C	MeSH

Chemical Formula

C₃₉H₆₂O₁₂

Average Mass

722.9130 Da

Monoisotopic Mass

722.42413 Da

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H]2O)O[C@]11CC[C@@H](C)CO1

InChI Identifier

InChI=1S/C39H62O12/c1-18-8-13-39(46-17-18)19(2)28-26(51-39)15-25-23-7-6-21-14-22(9-11-37(21,4)24(23)10-12-38(25,28)5)48-36-33(45)34(30(42)27(16-40)49-36)50-35-32(44)31(43)29(41)20(3)47-35/h6,18-20,22-36,40-45H,7-17H2,1-5H3/t18-,19+,20+,22+,23-,24+,25+,26+,27-,28+,29+,30-,31-,32-,33-,34+,35+,36-,37+,38+,39-/m1/s1

InChI Key

OJCPWEBMROBPTK-GTCMQMDYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Paris polyphylla	LOTUS Database	35616633
Tacca chantrieri	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as steroidal saponins. These are saponins in which the aglycone moiety is a steroid. The steroidal aglycone is usually a spirostane, furostane, spirosolane, solanidane, or curcubitacin derivative.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Steroidal glycosides

Direct Parent

Steroidal saponins

Alternative Parents

Substituents

Steroidal saponin
Triterpenoid
Spirostane skeleton
Delta-5-steroid
Disaccharide
Glycosyl compound
O-glycosyl compound
Ketal
Oxane
Tetrahydrofuran
Secondary alcohol
Polyol
Acetal
Oxacycle
Organoheterocyclic compound
Hydrocarbon derivative
Primary alcohol
Organooxygen compound
Alcohol
Organic oxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

23291695

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

44429637

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Wang J, Li X, Peng G, Fan G, Zhang M, Chen J: Integrated Bioinformatics Analysis and Verification of Gene Targets for Myocardial Ischemia-Reperfusion Injury. Evid Based Complement Alternat Med. 2022 Apr 15;2022:2056630. doi: 10.1155/2022/2056630. eCollection 2022. [PubMed:35463067 ]
Hua X, Song W, Wang K, Yin X, Hao C, Duan B, Xu Z, Su T, Xue Z: Effective prediction of biosynthetic pathway genes involved in bioactive polyphyllins in Paris polyphylla. Commun Biol. 2022 Jan 13;5(1):50. doi: 10.1038/s42003-022-03000-z. [PubMed:35027659 ]
Kondo Y, Watanabe S, Naoe A, Takeuchi T, Niimi A, Suzuki M, Asai N, Okada S, Tsuchiya T, Murayama M, Yasui T, Inoue M, Suzuki T: Antitumor effect of polyphyllin D on liver metastases of neuroblastoma. Pediatr Surg Int. 2022 Aug;38(8):1157-1163. doi: 10.1007/s00383-022-05146-7. Epub 2022 Jun 14. [PubMed:35699751 ]
Zirintunda G, Biryomumaisho S, Kasozi KI, Batiha GE, Kateregga J, Vudriko P, Nalule S, Olila D, Kajoba M, Matama K, Kwizera MR, Ghoneim MM, Abdelhamid M, Zaghlool SS, Alshehri S, Abdelgawad MA, Acai-Okwee J: Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution? Front Pharmacol. 2022 Feb 14;12:774896. doi: 10.3389/fphar.2021.774896. eCollection 2021. [PubMed:35237147 ]
Cheng G, Xue YY, Fang F, Sun GQ, Lu YY, Ji YQ, Qiu PC, Tang HF: Promotion of Ros-mediated Bax/Cyt-c apoptosis by polyphyllin II leads to suppress growth and aggression of glioma cells. Transl Cancer Res. 2021 Sep;10(9):3894-3905. doi: 10.21037/tcr-21-966. [PubMed:35116689 ]
Liu MM, Zhu ML, Dong RF, Zhang C, Zhang H, Yang L, Kong LY, Xia YZ: Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer. Chin J Nat Med. 2021 Apr;19(4):255-266. doi: 10.1016/S1875-5364(21)60027-4. [PubMed:33875166 ]
Zheng N, Zhang S, Wu W, Zhang N, Wang J: Regulatory mechanisms and therapeutic targeting of vasculogenic mimicry in hepatocellular carcinoma. Pharmacol Res. 2021 Apr;166:105507. doi: 10.1016/j.phrs.2021.105507. Epub 2021 Feb 18. [PubMed:33610718 ]
Xiao MF: [Effect of polyphyllin D on proliferation and apoptosis of human pancreatic cancer cells]. Zhongguo Zhong Yao Za Zhi. 2020 Mar;45(6):1418-1422. doi: 10.19540/j.cnki.cjcmm.20191230.401. [PubMed:32281356 ]
Li Q, Jiang W, Wan Z, Ni Y, Lei L, Wei J: Polyphyllin I attenuates pressure over-load induced cardiac hypertrophy via inhibition of Wnt/beta-catenin signaling pathway. Life Sci. 2020 Jul 1;252:117624. doi: 10.1016/j.lfs.2020.117624. Epub 2020 Apr 4. [PubMed:32259602 ]
Zeng Y, Zhang Z, Wang W, You L, Dong X, Yin X, Qu C, Ni J: Underlying mechanisms of apoptosis in HepG2 cells induced by polyphyllin I through Fas death and mitochondrial pathways. Toxicol Mech Methods. 2020 Jul;30(6):397-406. doi: 10.1080/15376516.2020.1747125. Epub 2020 Apr 14. [PubMed:32208876 ]

Showing NP-Card for Polyphyllin C (NP0140869)

MOL for NP0140869 (Polyphyllin C)

3D MOL for NP0140869 (Polyphyllin C)

3D SDF for NP0140869 (Polyphyllin C)

3D-SDF for NP0140869 (Polyphyllin C)

PDB for NP0140869 (Polyphyllin C)

3D PDB for NP0140869 (Polyphyllin C)

SMILES for NP0140869 (Polyphyllin C)

INCHI for NP0140869 (Polyphyllin C)

Structure for NP0140869 (Polyphyllin C)

3D Structure for NP0140869 (Polyphyllin C)