NP-MRD: Showing NP-Card for Pyrenulic acid E (NP0012942)

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Record Information

Version

1.0

Created at

2021-01-05 22:28:11 UTC

Updated at

2021-07-15 17:13:08 UTC

NP-MRD ID

NP0012942

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Pyrenulic acid E

Provided By

NPAtlas

Description

Pyrenulic acid E is also known as pyrenulate e. Pyrenulic acid E is found in Pyrenula sp. It was first documented in 2014 (PMID: 24926891). Based on a literature review very few articles have been published on Pyrenulic acid E.

Structure

MOL 3D MOL SDF 3D SDF PDB SMILES InChI


  Mrv1652306242119323D          

 69 71  0  0  0  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652306242119323D          

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    1.3675   -0.7064   -0.6669 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7714    0.4945   -0.6888 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7630    1.5497   -1.1002 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6020    2.0231   -0.1925 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5893    3.0549   -0.5455 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4132    3.5139    0.3633 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4005    4.5390    0.0312 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4816    5.0026   -1.1314 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2731    5.0269    0.9885 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0732    0.9715    0.5360 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2296    2.3354    0.2897 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1885    0.2759    0.8784 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.2550   -1.1647    0.3807 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7184   -1.3082   -0.9811 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2008   -2.0509   -2.1204 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8634   -0.6176   -1.2336 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4442    0.1549   -0.1027 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.6569    0.9336   -0.5654 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.0288    2.0173    0.3388 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4299    2.5742    0.2660 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2155    2.5332    1.2099 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8278    2.0754    1.3754 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.3520    1.0829    0.3739 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0816   -1.9625    0.8530 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3815   -3.4205    0.7735 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1349   -1.7218    2.2779 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0797   -5.3755   -1.1221 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4785   -4.7269    0.4773 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4045   -4.1130   -1.0013 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6745   -2.8021   -1.6675 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4017   -3.8705   -1.0731 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3302   -3.1829    1.3165 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7754   -1.2412    1.4071 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4490   -2.6823    0.4904 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8451   -1.1591   -0.3718 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6676   -0.7671    1.2793 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0003    0.5074   -1.5140 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8190    1.9387   -2.1110 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5590    1.6455    0.8172 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6528    3.4459   -1.5398 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3744    3.1390    1.3768 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1706    5.4323    0.7717 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7227    1.0176    1.4360 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1851    2.5661   -0.6504 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3039    0.2711    2.0066 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1122   -1.5892    1.0097 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8864   -2.8903   -2.4486 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2235   -1.3655   -3.0244 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1840   -2.4203   -2.0851 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3335   -0.6232   -2.1990 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7766   -0.4682    0.7339 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5205    0.2217   -0.6269 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4906    1.2864   -1.6108 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8574    2.3364   -0.7190 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9800    2.0835    1.1011 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3983    3.6700    0.4765 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5365    3.3465    1.8696 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1947    3.0133    1.3108 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6841    1.7070    2.4384 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9891    1.6226   -0.5492 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7548   -3.7793   -0.2063 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4490   -4.0918    1.0667 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1646   -3.6422    1.5745 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0850   -1.8989    2.5595 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
  7 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 18 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  1  0  0  0
 29  5  1  0  0  0  0
 28 17  1  0  0  0  0
 28 22  1  0  0  0  0
  1 32  1  0  0  0  0
  1 33  1  0  0  0  0
  1 34  1  0  0  0  0
  2 35  1  0  0  0  0
  2 36  1  0  0  0  0
  3 37  1  1  0  0  0
  4 38  1  0  0  0  0
  4 39  1  0  0  0  0
  4 40  1  0  0  0  0
  5 41  1  1  0  0  0
  7 42  1  6  0  0  0
  8 43  1  0  0  0  0
  9 44  1  0  0  0  0
 10 45  1  0  0  0  0
 11 46  1  0  0  0  0
 14 47  1  0  0  0  0
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 20 53  1  0  0  0  0
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 21 55  1  0  0  0  0
 22 56  1  1  0  0  0
 23 57  1  0  0  0  0
 23 58  1  0  0  0  0
 25 59  1  0  0  0  0
 25 60  1  0  0  0  0
 25 61  1  0  0  0  0
 26 62  1  0  0  0  0
 27 63  1  0  0  0  0
 27 64  1  0  0  0  0
 28 65  1  6  0  0  0
 30 66  1  0  0  0  0
 30 67  1  0  0  0  0
 30 68  1  0  0  0  0
 31 69  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0012942

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H]OC(=O)C(\[H])=C(/[H])\C(\[H])=C(/[H])[C@@]1([H])O[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@](O[H])(C([H])([H])[H])[C@]2([H])C(=C([H])[C@]3([H])C([H])([H])C(=C([H])C([H])([H])[C@@]3([H])[C@]2([H])[C@]1([H])O[H])C([H])([H])[H])C([H])([H])[H]

> <INCHI_IDENTIFIER>
InChI=1S/C26H38O5/c1-6-16(3)25-26(5,30)23-17(4)14-18-13-15(2)11-12-19(18)22(23)24(29)20(31-25)9-7-8-10-21(27)28/h7-11,14,16,18-20,22-25,29-30H,6,12-13H2,1-5H3,(H,27,28)/b9-7+,10-8+/t16-,18+,19-,20-,22+,23-,24-,25-,26+/m1/s1

> <INCHI_KEY>
NEZOHSNNESSNOS-OMBAGNCPSA-N

> <FORMULA>
C26H38O5

> <MOLECULAR_WEIGHT>
430.585

> <EXACT_MASS>
430.271924324

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
69

> <JCHEM_AVERAGE_POLARIZABILITY>
49.73874673319615

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2E,4E)-5-[(1S,2R,4R,5S,5aS,7aR,11aR,11bS)-4-[(2R)-butan-2-yl]-1,5-dihydroxy-5,6,9-trimethyl-1H,2H,4H,5H,5aH,7aH,8H,11H,11aH,11bH-naphtho[1,2-d]oxepin-2-yl]penta-2,4-dienoic acid

> <ALOGPS_LOGP>
4.07

> <JCHEM_LOGP>
3.960949469666665

> <ALOGPS_LOGS>
-4.21

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
13.492986922565429

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.030325093605723

> <JCHEM_PKA_STRONGEST_BASIC>
-3.298555520191419

> <JCHEM_POLAR_SURFACE_AREA>
86.99000000000001

> <JCHEM_REFRACTIVITY>
125.23639999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.63e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(2E,4E)-5-[(1S,2R,4R,5S,5aS,7aR,11aR,11bS)-4-[(2R)-butan-2-yl]-1,5-dihydroxy-5,6,9-trimethyl-1H,2H,4H,5aH,7aH,8H,11H,11aH,11bH-naphtho[1,2-d]oxepin-2-yl]penta-2,4-dienoic acid

> <JCHEM_VEBER_RULE>
0

$$$$

     RDKit          3D

 69 71  0  0  0  0  0  0  0  0999 V2000
    3.4412   -4.4699   -0.6177 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3343   -3.4149   -0.7768 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3348   -2.5275    0.4139 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.7243   -1.8669    0.4679 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2470   -1.4882    0.4631 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.3675   -0.7064   -0.6669 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7714    0.4945   -0.6888 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7630    1.5497   -1.1002 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6020    2.0231   -0.1925 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5893    3.0549   -0.5455 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4132    3.5139    0.3633 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4005    4.5390    0.0312 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4816    5.0026   -1.1314 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2731    5.0269    0.9885 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0732    0.9715    0.5360 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2296    2.3354    0.2897 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1885    0.2759    0.8784 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.2550   -1.1647    0.3807 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7184   -1.3082   -0.9811 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2008   -2.0509   -2.1204 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8634   -0.6176   -1.2336 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4442    0.1549   -0.1027 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.6569    0.9336   -0.5654 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0288    2.0173    0.3388 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4299    2.5742    0.2660 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2155    2.5332    1.2099 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8278    2.0754    1.3754 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3520    1.0829    0.3739 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0816   -1.9625    0.8530 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3815   -3.4205    0.7735 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1349   -1.7218    2.2779 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0797   -5.3755   -1.1221 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4785   -4.7269    0.4773 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4045   -4.1130   -1.0013 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6745   -2.8021   -1.6675 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4017   -3.8705   -1.0731 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3302   -3.1829    1.3165 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7754   -1.2412    1.4071 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4490   -2.6823    0.4904 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8451   -1.1591   -0.3718 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6676   -0.7671    1.2793 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0003    0.5074   -1.5140 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8190    1.9387   -2.1110 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5590    1.6455    0.8172 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6528    3.4459   -1.5398 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3744    3.1390    1.3768 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1706    5.4323    0.7717 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7227    1.0176    1.4360 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1851    2.5661   -0.6504 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3039    0.2711    2.0066 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1122   -1.5892    1.0097 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8864   -2.8903   -2.4486 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2235   -1.3655   -3.0244 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1840   -2.4203   -2.0851 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3335   -0.6232   -2.1990 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7766   -0.4682    0.7339 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5205    0.2217   -0.6269 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4906    1.2864   -1.6108 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8574    2.3364   -0.7190 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9800    2.0835    1.1011 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3983    3.6700    0.4765 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5365    3.3465    1.8696 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1947    3.0133    1.3108 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6841    1.7070    2.4384 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9891    1.6226   -0.5492 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7548   -3.7793   -0.2063 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4490   -4.0918    1.0667 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1646   -3.6422    1.5745 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0850   -1.8989    2.5595 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
  7 15  1  0
 15 16  1  0
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  2  0
 26 27  1  0
 27 28  1  0
 18 29  1  0
 29 30  1  0
 29 31  1  1
 29  5  1  0
 28 17  1  0
 28 22  1  0
  1 32  1  0
  1 33  1  0
  1 34  1  0
  2 35  1  0
  2 36  1  0
  3 37  1  1
  4 38  1  0
  4 39  1  0
  4 40  1  0
  5 41  1  1
  7 42  1  6
  8 43  1  0
  9 44  1  0
 10 45  1  0
 11 46  1  0
 14 47  1  0
 15 48  1  1
 16 49  1  0
 17 50  1  1
 18 51  1  1
 20 52  1  0
 20 53  1  0
 20 54  1  0
 21 55  1  0
 22 56  1  1
 23 57  1  0
 23 58  1  0
 25 59  1  0
 25 60  1  0
 25 61  1  0
 26 62  1  0
 27 63  1  0
 27 64  1  0
 28 65  1  6
 30 66  1  0
 30 67  1  0
 30 68  1  0
 31 69  1  0
M  END

HEADER    PROTEIN                                 24-JUN-21   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-JUN-21         0                                  
HETATM    1  C   UNK     0       3.441  -4.470  -0.618  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.334  -3.415  -0.777  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.335  -2.527   0.414  0.00  0.00           C+0
HETATM    4  C   UNK     0       3.724  -1.867   0.468  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.247  -1.488   0.463  0.00  0.00           C+0
HETATM    6  O   UNK     0       1.367  -0.706  -0.667  0.00  0.00           O+0
HETATM    7  C   UNK     0       0.771   0.495  -0.689  0.00  0.00           C+0
HETATM    8  C   UNK     0       1.763   1.550  -1.100  0.00  0.00           C+0
HETATM    9  C   UNK     0       2.602   2.023  -0.193  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.589   3.055  -0.546  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.413   3.514   0.363  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.401   4.539   0.031  0.00  0.00           C+0
HETATM   13  O   UNK     0       5.482   5.003  -1.131  0.00  0.00           O+0
HETATM   14  O   UNK     0       6.273   5.027   0.989  0.00  0.00           O+0
HETATM   15  C   UNK     0       0.073   0.972   0.536  0.00  0.00           C+0
HETATM   16  O   UNK     0      -0.230   2.335   0.290  0.00  0.00           O+0
HETATM   17  C   UNK     0      -1.188   0.276   0.878  0.00  0.00           C+0
HETATM   18  C   UNK     0      -1.255  -1.165   0.381  0.00  0.00           C+0
HETATM   19  C   UNK     0      -1.718  -1.308  -0.981  0.00  0.00           C+0
HETATM   20  C   UNK     0      -1.201  -2.051  -2.120  0.00  0.00           C+0
HETATM   21  C   UNK     0      -2.863  -0.618  -1.234  0.00  0.00           C+0
HETATM   22  C   UNK     0      -3.444   0.155  -0.103  0.00  0.00           C+0
HETATM   23  C   UNK     0      -4.657   0.934  -0.565  0.00  0.00           C+0
HETATM   24  C   UNK     0      -5.029   2.017   0.339  0.00  0.00           C+0
HETATM   25  C   UNK     0      -6.430   2.574   0.266  0.00  0.00           C+0
HETATM   26  C   UNK     0      -4.215   2.533   1.210  0.00  0.00           C+0
HETATM   27  C   UNK     0      -2.828   2.075   1.375  0.00  0.00           C+0
HETATM   28  C   UNK     0      -2.352   1.083   0.374  0.00  0.00           C+0
HETATM   29  C   UNK     0      -0.082  -1.962   0.853  0.00  0.00           C+0
HETATM   30  C   UNK     0      -0.382  -3.421   0.774  0.00  0.00           C+0
HETATM   31  O   UNK     0      -0.135  -1.722   2.278  0.00  0.00           O+0
HETATM   32  H   UNK     0       3.080  -5.375  -1.122  0.00  0.00           H+0
HETATM   33  H   UNK     0       3.478  -4.727   0.477  0.00  0.00           H+0
HETATM   34  H   UNK     0       4.404  -4.113  -1.001  0.00  0.00           H+0
HETATM   35  H   UNK     0       2.675  -2.802  -1.668  0.00  0.00           H+0
HETATM   36  H   UNK     0       1.402  -3.870  -1.073  0.00  0.00           H+0
HETATM   37  H   UNK     0       2.330  -3.183   1.317  0.00  0.00           H+0
HETATM   38  H   UNK     0       3.775  -1.241   1.407  0.00  0.00           H+0
HETATM   39  H   UNK     0       4.449  -2.682   0.490  0.00  0.00           H+0
HETATM   40  H   UNK     0       3.845  -1.159  -0.372  0.00  0.00           H+0
HETATM   41  H   UNK     0       1.668  -0.767   1.279  0.00  0.00           H+0
HETATM   42  H   UNK     0      -0.000   0.507  -1.514  0.00  0.00           H+0
HETATM   43  H   UNK     0       1.819   1.939  -2.111  0.00  0.00           H+0
HETATM   44  H   UNK     0       2.559   1.646   0.817  0.00  0.00           H+0
HETATM   45  H   UNK     0       3.653   3.446  -1.540  0.00  0.00           H+0
HETATM   46  H   UNK     0       4.374   3.139   1.377  0.00  0.00           H+0
HETATM   47  H   UNK     0       7.171   5.432   0.772  0.00  0.00           H+0
HETATM   48  H   UNK     0       0.723   1.018   1.436  0.00  0.00           H+0
HETATM   49  H   UNK     0      -0.185   2.566  -0.650  0.00  0.00           H+0
HETATM   50  H   UNK     0      -1.304   0.271   2.007  0.00  0.00           H+0
HETATM   51  H   UNK     0      -2.112  -1.589   1.010  0.00  0.00           H+0
HETATM   52  H   UNK     0      -1.886  -2.890  -2.449  0.00  0.00           H+0
HETATM   53  H   UNK     0      -1.224  -1.365  -3.024  0.00  0.00           H+0
HETATM   54  H   UNK     0      -0.184  -2.420  -2.085  0.00  0.00           H+0
HETATM   55  H   UNK     0      -3.333  -0.623  -2.199  0.00  0.00           H+0
HETATM   56  H   UNK     0      -3.777  -0.468   0.734  0.00  0.00           H+0
HETATM   57  H   UNK     0      -5.521   0.222  -0.627  0.00  0.00           H+0
HETATM   58  H   UNK     0      -4.491   1.286  -1.611  0.00  0.00           H+0
HETATM   59  H   UNK     0      -6.857   2.336  -0.719  0.00  0.00           H+0
HETATM   60  H   UNK     0      -6.980   2.083   1.101  0.00  0.00           H+0
HETATM   61  H   UNK     0      -6.398   3.670   0.477  0.00  0.00           H+0
HETATM   62  H   UNK     0      -4.537   3.346   1.870  0.00  0.00           H+0
HETATM   63  H   UNK     0      -2.195   3.013   1.311  0.00  0.00           H+0
HETATM   64  H   UNK     0      -2.684   1.707   2.438  0.00  0.00           H+0
HETATM   65  H   UNK     0      -1.989   1.623  -0.549  0.00  0.00           H+0
HETATM   66  H   UNK     0      -0.755  -3.779  -0.206  0.00  0.00           H+0
HETATM   67  H   UNK     0       0.449  -4.092   1.067  0.00  0.00           H+0
HETATM   68  H   UNK     0      -1.165  -3.642   1.575  0.00  0.00           H+0
HETATM   69  H   UNK     0      -1.085  -1.899   2.559  0.00  0.00           H+0
CONECT    1    2   32   33   34                                             
CONECT    2    1    3   35   36                                             
CONECT    3    2    4    5   37                                             
CONECT    4    3   38   39   40                                             
CONECT    5    3    6   29   41                                             
CONECT    6    5    7                                                       
CONECT    7    6    8   15   42                                             
CONECT    8    7    9   43                                                  
CONECT    9    8   10   44                                                  
CONECT   10    9   11   45                                                  
CONECT   11   10   12   46                                                  
CONECT   12   11   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   47                                                       
CONECT   15    7   16   17   48                                             
CONECT   16   15   49                                                       
CONECT   17   15   18   28   50                                             
CONECT   18   17   19   29   51                                             
CONECT   19   18   20   21                                                  
CONECT   20   19   52   53   54                                             
CONECT   21   19   22   55                                                  
CONECT   22   21   23   28   56                                             
CONECT   23   22   24   57   58                                             
CONECT   24   23   25   26                                                  
CONECT   25   24   59   60   61                                             
CONECT   26   24   27   62                                                  
CONECT   27   26   28   63   64                                             
CONECT   28   27   17   22   65                                             
CONECT   29   18   30   31    5                                             
CONECT   30   29   66   67   68                                             
CONECT   31   29   69                                                       
CONECT   32    1                                                            
CONECT   33    1                                                            
CONECT   34    1                                                            
CONECT   35    2                                                            
CONECT   36    2                                                            
CONECT   37    3                                                            
CONECT   38    4                                                            
CONECT   39    4                                                            
CONECT   40    4                                                            
CONECT   41    5                                                            
CONECT   42    7                                                            
CONECT   43    8                                                            
CONECT   44    9                                                            
CONECT   45   10                                                            
CONECT   46   11                                                            
CONECT   47   14                                                            
CONECT   48   15                                                            
CONECT   49   16                                                            
CONECT   50   17                                                            
CONECT   51   18                                                            
CONECT   52   20                                                            
CONECT   53   20                                                            
CONECT   54   20                                                            
CONECT   55   21                                                            
CONECT   56   22                                                            
CONECT   57   23                                                            
CONECT   58   23                                                            
CONECT   59   25                                                            
CONECT   60   25                                                            
CONECT   61   25                                                            
CONECT   62   26                                                            
CONECT   63   27                                                            
CONECT   64   27                                                            
CONECT   65   28                                                            
CONECT   66   30                                                            
CONECT   67   30                                                            
CONECT   68   30                                                            
CONECT   69   31                                                            
MASTER        0    0    0    0    0    0    0    0   69    0  142    0
END

RDKit          3D

69 71  0  0  0  0  0  0  0  0999 V2000
    3.4412   -4.4699   -0.6177 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3343   -3.4149   -0.7768 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3348   -2.5275    0.4139 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.7243   -1.8669    0.4679 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2470   -1.4882    0.4631 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.3675   -0.7064   -0.6669 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7714    0.4945   -0.6888 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7630    1.5497   -1.1002 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6020    2.0231   -0.1925 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5893    3.0549   -0.5455 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4132    3.5139    0.3633 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4005    4.5390    0.0312 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4816    5.0026   -1.1314 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2731    5.0269    0.9885 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0732    0.9715    0.5360 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2296    2.3354    0.2897 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1885    0.2759    0.8784 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.2550   -1.1647    0.3807 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.7184   -1.3082   -0.9811 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2008   -2.0509   -2.1204 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8634   -0.6176   -1.2336 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4442    0.1549   -0.1027 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.6569    0.9336   -0.5654 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0288    2.0173    0.3388 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4299    2.5742    0.2660 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2155    2.5332    1.2099 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8278    2.0754    1.3754 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3520    1.0829    0.3739 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0816   -1.9625    0.8530 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3815   -3.4205    0.7735 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1349   -1.7218    2.2779 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0797   -5.3755   -1.1221 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4785   -4.7269    0.4773 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4045   -4.1130   -1.0013 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6745   -2.8021   -1.6675 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4017   -3.8705   -1.0731 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3302   -3.1829    1.3165 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7754   -1.2412    1.4071 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4490   -2.6823    0.4904 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8451   -1.1591   -0.3718 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6676   -0.7671    1.2793 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0003    0.5074   -1.5140 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8190    1.9387   -2.1110 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5590    1.6455    0.8172 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6528    3.4459   -1.5398 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3744    3.1390    1.3768 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1706    5.4323    0.7717 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7227    1.0176    1.4360 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1851    2.5661   -0.6504 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3039    0.2711    2.0066 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1122   -1.5892    1.0097 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8864   -2.8903   -2.4486 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2235   -1.3655   -3.0244 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1840   -2.4203   -2.0851 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3335   -0.6232   -2.1990 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7766   -0.4682    0.7339 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5205    0.2217   -0.6269 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4906    1.2864   -1.6108 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8574    2.3364   -0.7190 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9800    2.0835    1.1011 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3983    3.6700    0.4765 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5365    3.3465    1.8696 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1947    3.0133    1.3108 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6841    1.7070    2.4384 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9891    1.6226   -0.5492 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7548   -3.7793   -0.2063 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4490   -4.0918    1.0667 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1646   -3.6422    1.5745 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0850   -1.8989    2.5595 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
  7 15  1  0
 15 16  1  0
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  2  0
 26 27  1  0
 27 28  1  0
 18 29  1  0
 29 30  1  0
 29 31  1  1
 29  5  1  0
 28 17  1  0
 28 22  1  0
  1 32  1  0
  1 33  1  0
  1 34  1  0
  2 35  1  0
  2 36  1  0
  3 37  1  1
  4 38  1  0
  4 39  1  0
  4 40  1  0
  5 41  1  1
  7 42  1  6
  8 43  1  0
  9 44  1  0
 10 45  1  0
 11 46  1  0
 14 47  1  0
 15 48  1  1
 16 49  1  0
 17 50  1  1
 18 51  1  1
 20 52  1  0
 20 53  1  0
 20 54  1  0
 21 55  1  0
 22 56  1  1
 23 57  1  0
 23 58  1  0
 25 59  1  0
 25 60  1  0
 25 61  1  0
 26 62  1  0
 27 63  1  0
 27 64  1  0
 28 65  1  6
 30 66  1  0
 30 67  1  0
 30 68  1  0
 31 69  1  0
M  END

View in JSmol View NMR Assignments

Synonyms

Value	Source
Pyrenulate e	Generator
(2E,4E)-5-[(1S,2R,4R,5S,5AS,7ar,11ar,11BS)-4-[(2R)-butan-2-yl]-1,5-dihydroxy-5,6,9-trimethyl-1H,2H,4H,5H,5ah,7ah,8H,11H,11ah,11BH-naphtho[1,2-D]oxepin-2-yl]penta-2,4-dienoate	Generator

Chemical Formula

C₂₆H₃₈O₅

Average Mass

430.5850 Da

Monoisotopic Mass

430.27192 Da

IUPAC Name

(2E,4E)-5-[(1S,2R,4R,5S,5aS,7aR,11aR,11bS)-4-[(2R)-butan-2-yl]-1,5-dihydroxy-5,6,9-trimethyl-1H,2H,4H,5H,5aH,7aH,8H,11H,11aH,11bH-naphtho[1,2-d]oxepin-2-yl]penta-2,4-dienoic acid

Traditional Name

(2E,4E)-5-[(1S,2R,4R,5S,5aS,7aR,11aR,11bS)-4-[(2R)-butan-2-yl]-1,5-dihydroxy-5,6,9-trimethyl-1H,2H,4H,5aH,7aH,8H,11H,11aH,11bH-naphtho[1,2-d]oxepin-2-yl]penta-2,4-dienoic acid

CAS Registry Number

Not Available

SMILES

CC[C@@H](C)[C@H]1O[C@H](\C=C\C=C\C(O)=O)[C@@H](O)[C@H]2[C@@H]3CC=C(C)C[C@H]3C=C(C)[C@H]2[C@]1(C)O

InChI Identifier

InChI=1S/C26H38O5/c1-6-16(3)25-26(5,30)23-17(4)14-18-13-15(2)11-12-19(18)22(23)24(29)20(31-25)9-7-8-10-21(27)28/h7-11,14,16,18-20,22-25,29-30H,6,12-13H2,1-5H3,(H,27,28)/b9-7+,10-8+/t16-,18+,19-,20-,22+,23-,24-,25-,26+/m1/s1

InChI Key

NEZOHSNNESSNOS-OMBAGNCPSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Pyrenula sp.	NPAtlas	24926891

Chemical Taxonomy

Classification

Not classified

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.07	ALOGPS
logP	3.96	ChemAxon
logS	-4.2	ALOGPS
pKa (Strongest Acidic)	4.03	ChemAxon
pKa (Strongest Basic)	-3.3	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	86.99 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	125.24 m³·mol⁻¹	ChemAxon
Polarizability	49.74 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

NPAtlas ID

NPA010262

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

78437485

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

139585936

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Le DH, Takenaka Y, Hamada N, Mizushina Y, Tanahashi T: Polyketides from the cultured lichen mycobiont of a Vietnamese Pyrenula sp. J Nat Prod. 2014 Jun 27;77(6):1404-12. doi: 10.1021/np500143k. Epub 2014 Jun 13. [PubMed:24926891 ]

Showing NP-Card for Pyrenulic acid E (NP0012942)

MOL for NP0012942 (Pyrenulic acid E)

3D MOL for NP0012942 (Pyrenulic acid E)

3D SDF for NP0012942 (Pyrenulic acid E)

3D-SDF for NP0012942 (Pyrenulic acid E)

PDB for NP0012942 (Pyrenulic acid E)

3D PDB for NP0012942 (Pyrenulic acid E)

SMILES for NP0012942 (Pyrenulic acid E)

INCHI for NP0012942 (Pyrenulic acid E)

Structure for NP0012942 (Pyrenulic acid E)

3D Structure for NP0012942 (Pyrenulic acid E)