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Showing NP-Card for m-Coumaric acid (NP0000467)

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Record Information
Version1.0
Created at2005-11-20 22:13:20 UTC
Updated at2024-04-19 10:06:02 UTC
NP-MRD IDNP0000467
Secondary Accession NumbersNone
Natural Product Identification
Common Namem-Coumaric acid
DescriptionM-Coumaric acid, also known as 3-coumarate, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. M-Coumaric acid exists in all living organisms, ranging from bacteria to humans. M-Coumaric acid (CAS: 588-30-7) Is a polyphenol metabolite from caffeic acid, formed by the gut microflora. Outside of the human body, m-Coumaric acid is found, on average, in the highest concentration within a few different foods, such as olives, corns, and beers. M-Coumaric acid has also been detected, but not quantified in several different foods, such as carrots, strawberries, grape wines, garden tomato, and bilberries. MCT-mediated absorption of phenolic compounds per se and their colonic metabolites would exert a significant impact on human health (PMID: 16870009 , 15479001 , 15479001 ). M-Coumaric acid is transported by the monocarboxylic acid transporter (MCT). The amount of this compound in human biofluids is diet-dependant. M-Coumaric acid is detected after the consumption of whole grain.
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for NP0000467 (m-Coumaric acid)


  Mrv1652306131923232D          

 12 12  0  0  0  0            999 V2000
   -1.6292   -0.5026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3436   -0.0901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0582   -0.5027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0582   -1.3276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3438   -1.7401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6292   -1.3276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9148   -0.0900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2003   -0.5025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5141   -0.0900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2286   -0.5025    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5141    0.7349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7727   -0.0902    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  1  1  0  0  0  0
  1  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
  3 12  1  0  0  0  0
M  END
Download

3D MOL for NP0000467 (m-Coumaric acid)

HMDB0001713
     RDKit          3D
m-Coumaric acid
 20 20  0  0  0  0  0  0  0  0999 V2000
    3.7702    1.2928    0.3919 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5260    0.0504    0.3442 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5627   -0.8855    0.3636 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1510   -0.4197    0.2680 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1728    0.4717    0.2500 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2375    0.1160    0.1756 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6392   -1.1961    0.1187 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0102   -1.4436    0.0493 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9466   -0.4411    0.0364 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5392    0.8573    0.0931 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4514    1.9319    0.0834 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1934    1.1254    0.1620 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3489   -0.8681   -0.2532 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9516   -1.4779    0.2278 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4112    1.5530    0.2927 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0675   -2.0295    0.1262 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3009   -2.4997    0.0050 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0028   -0.6698   -0.0183 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7575    2.3640   -0.7844 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8833    2.1685    0.2068 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
 12  6  1  0
  3 13  1  0
  4 14  1  0
  5 15  1  0
  7 16  1  0
  8 17  1  0
  9 18  1  0
 11 19  1  0
 12 20  1  0
M  END
Download

3D SDF for NP0000467 (m-Coumaric acid)


  Mrv1652306131923232D          

 12 12  0  0  0  0            999 V2000
   -1.6292   -0.5026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3436   -0.0901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0582   -0.5027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0582   -1.3276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3438   -1.7401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6292   -1.3276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9148   -0.0900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2003   -0.5025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5141   -0.0900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2286   -0.5025    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5141    0.7349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7727   -0.0902    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  1  1  0  0  0  0
  1  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
  3 12  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0000467

> <DATABASE_NAME>
NP-MRD

> <SMILES>
OC(=O)\C=C\C1=CC(O)=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C9H8O3/c10-8-3-1-2-7(6-8)4-5-9(11)12/h1-6,10H,(H,11,12)/b5-4+

> <INCHI_KEY>
KKSDGJDHHZEWEP-SNAWJCMRSA-N

> <FORMULA>
C9H8O3

> <MOLECULAR_WEIGHT>
164.158

> <EXACT_MASS>
164.047344122

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
20

> <JCHEM_AVERAGE_POLARIZABILITY>
16.37256447757347

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2E)-3-(3-hydroxyphenyl)prop-2-enoic acid

> <ALOGPS_LOGP>
1.71

> <JCHEM_LOGP>
1.832520938333333

> <ALOGPS_LOGS>
-2.20

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
9.42942136236343

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.014955066115015

> <JCHEM_PKA_STRONGEST_BASIC>
-5.9719429291949035

> <JCHEM_POLAR_SURFACE_AREA>
57.53

> <JCHEM_REFRACTIVITY>
45.040800000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.04e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
m-coumaric acid

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for NP0000467 (m-Coumaric acid)

HMDB0001713
     RDKit          3D
m-Coumaric acid
 20 20  0  0  0  0  0  0  0  0999 V2000
    3.7702    1.2928    0.3919 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5260    0.0504    0.3442 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5627   -0.8855    0.3636 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1510   -0.4197    0.2680 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1728    0.4717    0.2500 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2375    0.1160    0.1756 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6392   -1.1961    0.1187 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0102   -1.4436    0.0493 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9466   -0.4411    0.0364 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5392    0.8573    0.0931 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4514    1.9319    0.0834 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1934    1.1254    0.1620 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3489   -0.8681   -0.2532 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9516   -1.4779    0.2278 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4112    1.5530    0.2927 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0675   -2.0295    0.1262 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3009   -2.4997    0.0050 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0028   -0.6698   -0.0183 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7575    2.3640   -0.7844 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8833    2.1685    0.2068 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0
  2  3  1  0
  2  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
 12  6  1  0
  3 13  1  0
  4 14  1  0
  5 15  1  0
  7 16  1  0
  8 17  1  0
  9 18  1  0
 11 19  1  0
 12 20  1  0
M  END
Download

PDB for NP0000467 (m-Coumaric acid)

HEADER    PROTEIN                                 13-JUN-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   13-JUN-19         0                                  
HETATM    1  C   UNK     0      -3.041  -0.938   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -4.375  -0.168   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -5.709  -0.938   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -5.709  -2.478   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -4.375  -3.248   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -3.041  -2.478   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -1.708  -0.168   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -0.374  -0.938   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       0.960  -0.168   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       2.293  -0.938   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0       0.960   1.372   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0      -7.042  -0.168   0.000  0.00  0.00           O+0
CONECT    1    2    6    7                                                  
CONECT    2    1    3                                                       
CONECT    3    2    4   12                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    1                                                       
CONECT    7    1    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9                                                            
CONECT   12    3                                                            
MASTER        0    0    0    0    0    0    0    0   12    0   24    0
END
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3D PDB for NP0000467 (m-Coumaric acid)

COMPND    HMDB0001713
HETATM    1  O1  UNL     1       3.770   1.293   0.392  1.00  0.00           O  
HETATM    2  C1  UNL     1       3.526   0.050   0.344  1.00  0.00           C  
HETATM    3  O2  UNL     1       4.563  -0.886   0.364  1.00  0.00           O  
HETATM    4  C2  UNL     1       2.151  -0.420   0.268  1.00  0.00           C  
HETATM    5  C3  UNL     1       1.173   0.472   0.250  1.00  0.00           C  
HETATM    6  C4  UNL     1      -0.238   0.116   0.176  1.00  0.00           C  
HETATM    7  C5  UNL     1      -0.639  -1.196   0.119  1.00  0.00           C  
HETATM    8  C6  UNL     1      -2.010  -1.444   0.049  1.00  0.00           C  
HETATM    9  C7  UNL     1      -2.947  -0.441   0.036  1.00  0.00           C  
HETATM   10  C8  UNL     1      -2.539   0.857   0.093  1.00  0.00           C  
HETATM   11  O3  UNL     1      -3.451   1.932   0.083  1.00  0.00           O  
HETATM   12  C9  UNL     1      -1.193   1.125   0.162  1.00  0.00           C  
HETATM   13  H1  UNL     1       5.349  -0.868  -0.253  1.00  0.00           H  
HETATM   14  H2  UNL     1       1.952  -1.478   0.228  1.00  0.00           H  
HETATM   15  H3  UNL     1       1.411   1.553   0.293  1.00  0.00           H  
HETATM   16  H4  UNL     1       0.068  -2.029   0.126  1.00  0.00           H  
HETATM   17  H5  UNL     1      -2.301  -2.500   0.005  1.00  0.00           H  
HETATM   18  H6  UNL     1      -4.003  -0.670  -0.018  1.00  0.00           H  
HETATM   19  H7  UNL     1      -3.757   2.364  -0.784  1.00  0.00           H  
HETATM   20  H8  UNL     1      -0.883   2.168   0.207  1.00  0.00           H  
CONECT    1    2    2
CONECT    2    3    4
CONECT    3   13
CONECT    4    5    5   14
CONECT    5    6   15
CONECT    6    7    7   12
CONECT    7    8   16
CONECT    8    9    9   17
CONECT    9   10   18
CONECT   10   11   12   12
CONECT   11   19
CONECT   12   20
END
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SMILES for NP0000467 (m-Coumaric acid)

OC(=O)\C=C\C1=CC(O)=CC=C1
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INCHI for NP0000467 (m-Coumaric acid)

InChI=1S/C9H8O3/c10-8-3-1-2-7(6-8)4-5-9(11)12/h1-6,10H,(H,11,12)/b5-4+
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View in JSmol
Synonyms
ValueSource
(2E)-3-(3-Hydroxyphenyl)-2-propenoic acidChEBI
(2E)-3-(3-Hydroxyphenyl)acrylic acidChEBI
(e)-3-(3-Hydroxyphenyl)-2-propenoic acidChEBI
3-Coumaric acidChEBI
m-Hydroxycinnamic acidChEBI
trans-3-HydroxycinnamateChEBI
trans-3-Hydroxycinnamic acidChEBI
(2E)-3-(3-Hydroxyphenyl)prop-2-enoateKegg
(2E)-3-(3-Hydroxyphenyl)-2-propenoateGenerator
(2E)-3-(3-Hydroxyphenyl)acrylateGenerator
(e)-3-(3-Hydroxyphenyl)-2-propenoateGenerator
3-CoumarateGenerator
m-HydroxycinnamateGenerator
(2E)-3-(3-Hydroxyphenyl)prop-2-enoic acidGenerator
m-CoumarateGenerator
3'-HydroxycinnamateHMDB
3'-Hydroxycinnamic acidHMDB
3-(3-Hydroxyphenyl)-2-propenoateHMDB
3-(3-Hydroxyphenyl)-2-propenoic acidHMDB
3-(3-Hydroxyphenyl)acrylateHMDB
3-(3-Hydroxyphenyl)acrylsaeureHMDB
3-(3-Hydroxyphenyl)prop-2-enoateHMDB
3-(3-Hydroxyphenyl)prop-2-enoic acidHMDB
3-HydroxycinnamateHMDB
3-Hydroxycinnamic acidHMDB
m-Hydroxy-cinnamateHMDB
m-Hydroxy-cinnamic acidHMDB
3-Coumaric acid, (e)-isomerHMDB
Meta-coumaric acidHMDB
(e)-3-(3-Hydroxyphenyl)acrylic acidHMDB
(e)-3-Hydroxycinnamic acidHMDB
trans-3-(m-Hydroxyphenyl)-2-propenoic acidHMDB
trans-m-Coumaric acidHMDB
trans-m-Hydroxycinnamic acidHMDB
trans-3-CoumarateHMDB
3-(3-Hydroxyphenyl)acrylic acidHMDB
trans-3-Coumaric acidHMDB
m-Coumaric acidHMDB
Chemical FormulaC9H8O3
Average Mass164.1580 Da
Monoisotopic Mass164.04734 Da
IUPAC Name(2E)-3-(3-hydroxyphenyl)prop-2-enoic acid
Traditional Namem-coumaric acid
CAS Registry Number588-30-7
SMILES
OC(=O)\C=C\C1=CC(O)=CC=C1
InChI Identifier
InChI=1S/C9H8O3/c10-8-3-1-2-7(6-8)4-5-9(11)12/h1-6,10H,(H,11,12)/b5-4+
InChI KeyKKSDGJDHHZEWEP-SNAWJCMRSA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
COSY NMR[1H, 1H] NMR Spectrum (2D, 600 MHz, CD3OD, experimental)bgnzk@missouri.eduMU Metabolomics Center, University of Missouri, Columbia. MO, USADr. Bharat Goel2024-01-23View Spectrum
HMBC NMR[1H, 13C] NMR Spectrum (2D, 600 MHz, CD3OD, experimental)bgnzk@missouri.eduMU Metabolomics Center, University of Missouri, Columbia. MO, USADr. Bharat Goel2024-01-23View Spectrum
HSQC NMR[1H, 13C] NMR Spectrum (2D, 600 MHz, CD3OD, experimental)bgnzk@missouri.eduMU Metabolomics Center, University of Missouri, Columbia. MO, USADr. Bharat Goel2024-01-23View Spectrum
1D NMR[13C, ] NMR Spectrum (2D, 201 MHz, CD3OD, experimental)bgnzk@missouri.eduMU Metabolomics Center, University of Missouri, Columbia. MO, USADr. Bharat Goel2024-01-23View Spectrum
1D NMR[1H, ] NMR Spectrum (2D, 800 MHz, CD3OD, experimental)bgnzk@missouri.eduMU Metabolomics Center, University of Missouri, Columbia. MO, USADr. Bharat Goel2024-01-23View Spectrum
1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 800.148940889 MHz, CD3OD, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 201.216488466 MHz, CD3OD, simulated)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of Origin
Species NameSourceReference
Allium sativumKNApSAcK Database
Anas platyrhynchosFooDB
AnatidaeFooDB
Anser anserFooDB
Balanophora tobiracolaLOTUS Database
Betula pubescensLOTUS Database
Bison bisonFooDB
Bos taurusFooDB
Bos taurus X Bison bisonFooDB
Brassica oleracea var. italicaFooDB
Bubalus bubalisFooDB
Capra aegagrus hircusFooDB
CervidaeFooDB
Cervus canadensisFooDB
Coffea arabica L.FooDB
Coffea canephoraFooDB
ColumbaFooDB
ColumbidaeFooDB
Crataegus monogynaLOTUS Database
Daphnia pulexLOTUS Database
Daucus carota ssp. sativusFooDB
Dromaius novaehollandiaeFooDB
Equus caballusFooDB
Fragaria x ananassaFooDB
Gallus gallusFooDB
Gliricidia sepiumLOTUS Database
Lactuca sativaFooDB
Lagopus mutaFooDB
Lemna aequinoctialisLOTUS Database
LeporidaeFooDB
Lepus timidusFooDB
Malus pumilaFooDB
Melanitta fuscaFooDB
Meleagris gallopavoFooDB
Numida meleagrisFooDB
OdocoileusFooDB
Olea europaeaFooDB
OryctolagusFooDB
Ovis ariesFooDB
Persea americanaLOTUS Database
PhasianidaeFooDB
Phasianus colchicusFooDB
Pinus sibiricaKNApSAcK Database
Pyrus communisFooDB
    • A. Escarpa and M. C. Gonzalez. Evaluation of High-Performance Liquid Chromatography for Determina...
Raphanus sativusKNApSAcK Database
Rubus idaeusFooDB
Solanum lycopersicum var. lycopersicumFooDB
Spinacia oleraceaFooDB
Struthio camelusFooDB
Sus scrofaFooDB
Sus scrofa domesticaFooDB
Trigonella foenum-graecumLOTUS Database
Vaccinium myrtillusFooDB
VitisFooDB
Zea mays L.FooDB
Species Where Detected
Species NameSourceReference
Homo sapiens (Urine)KNApSAcK Database
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassCinnamic acids and derivatives
Sub ClassHydroxycinnamic acids and derivatives
Direct ParentHydroxycinnamic acids
Alternative Parents
Substituents
  • Cinnamic acid
  • Coumaric acid
  • Coumaric acid or derivatives
  • Hydroxycinnamic acid
  • Styrene
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Phenol
  • Monocyclic benzene moiety
  • Benzenoid
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic oxide
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point192 - 194 °CNot Available
Boiling Point373.00 to 374.00 °C. @ 760.00 mm Hg (est)The Good Scents Company Information System
Water Solubility27090 mg/L @ 25 °C (est)The Good Scents Company Information System
LogP1.826 (est)The Good Scents Company Information System
Predicted Properties
PropertyValueSource
Water Solubility1.04 g/LALOGPS
logP1.71ALOGPS
logP1.83ChemAxon
logS-2.2ALOGPS
pKa (Strongest Acidic)4.01ChemAxon
pKa (Strongest Basic)-6ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area57.53 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity45.04 m³·mol⁻¹ChemAxon
Polarizability16.37 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDHMDB0001713
DrugBank IDNot Available
Phenol Explorer Compound ID463
FoodDB IDFDB002591
KNApSAcK IDC00052344
Chemspider ID553147
KEGG Compound IDC12621
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkM-coumaric_acid
METLIN ID305
PubChem Compound637541
PDB IDNot Available
ChEBI ID32357
Good Scents IDrw1417071
References
General References
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  4. Kim MJ, Choi SJ, Kim HK, Kim CJ, Hong B, Kim YJ, Shin DH: Activation effects of Allium tuberosum Rottl. on choline acetyltransferase. Biosci Biotechnol Biochem. 2007 Jan;71(1):226-30. Epub 2007 Jan 7. [PubMed:17213651 ]
  5. Shahidi F, Alasalvar C, Liyana-Pathirana CM: Antioxidant phytochemicals in hazelnut kernel (Corylus avellana L.) and hazelnut byproducts. J Agric Food Chem. 2007 Feb 21;55(4):1212-20. Epub 2007 Jan 24. [PubMed:17249682 ]
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  7. Colen CB, Seraji-Bozorgzad N, Marples B, Galloway MP, Sloan AE, Mathupala SP: Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study. Neurosurgery. 2006 Dec;59(6):1313-23; discussion 1323-4. [PubMed:17277695 ]
  8. Luceri C, Giannini L, Lodovici M, Antonucci E, Abbate R, Masini E, Dolara P: p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo. Br J Nutr. 2007 Mar;97(3):458-63. [PubMed:17313706 ]
  9. Funk C, Braune A, Grabber JH, Steinhart H, Bunzel M: Moderate ferulate and diferulate levels do not impede maize cell wall degradation by human intestinal microbiota. J Agric Food Chem. 2007 Mar 21;55(6):2418-23. Epub 2007 Feb 24. [PubMed:17319685 ]
  10. Grande MJ, Lopez RL, Abriouel H, Valdivia E, Ben Omar N, Maqueda M, Martinez-Canamero M, Galvez A: Treatment of vegetable sauces with enterocin AS-48 alone or in combination with phenolic compounds to inhibit proliferation of Staphylococcus aureus. J Food Prot. 2007 Feb;70(2):405-11. [PubMed:17340876 ]
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  13. Azzini E, Bugianesi R, Romano F, Di Venere D, Miccadei S, Durazzo A, Foddai MS, Catasta G, Linsalata V, Maiani G: Absorption and metabolism of bioactive molecules after oral consumption of cooked edible heads of Cynara scolymus L. (cultivar Violetto di Provenza) in human subjects: a pilot study. Br J Nutr. 2007 May;97(5):963-9. [PubMed:17408528 ]
  14. Appiah-Opong R, Commandeur JN, van Vugt-Lussenburg B, Vermeulen NP: Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology. 2007 Jun 3;235(1-2):83-91. Epub 2007 Mar 15. [PubMed:17433521 ]
  15. Wang Q, Morris ME: The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. Drug Metab Dispos. 2007 Aug;35(8):1393-9. Epub 2007 May 14. [PubMed:17502341 ]
  16. Keyhanian S, Stahl-Biskup E: Phenolic constituents in dried flowers of aloe vera (Aloe barbadensis) and their in vitro antioxidative capacity. Planta Med. 2007 Jun;73(6):599-602. Epub 2007 May 22. [PubMed:17520524 ]
  17. Kosanam H, Prakash PK, Yates CR, Miller DD, Ramagiri S: Rapid screening of doping agents in human urine by vacuum MALDI-linear ion trap mass spectrometry. Anal Chem. 2007 Aug 1;79(15):6020-6. Epub 2007 Jun 30. [PubMed:17602668 ]
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  19. Gomez-Ruiz JA, Leake DS, Ames JM: In vitro antioxidant activity of coffee compounds and their metabolites. J Agric Food Chem. 2007 Aug 22;55(17):6962-9. Epub 2007 Jul 27. [PubMed:17655324 ]
  20. Wu CI, Tsai CC, Lu CC, Wu PC, Wu DC, Lin SY, Shiea J: Diagnosis of occult blood in human feces using matrix-assisted laser desorption ionization/time-of-flight mass spectrometry. Clin Chim Acta. 2007 Sep;384(1-2):86-92. Epub 2007 Jun 26. [PubMed:17662705 ]
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  22. Qin J, Chen D, Hu H, Qiao M, Zhao X, Chen B: Body distributioin of RGD-mediated liposome in brain-targeting drug delivery. Yakugaku Zasshi. 2007 Sep;127(9):1497-501. [PubMed:17827930 ]
  23. Monteiro M, Farah A, Perrone D, Trugo LC, Donangelo C: Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans. J Nutr. 2007 Oct;137(10):2196-201. [PubMed:17884997 ]
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  25. Konishi Y, Kobayashi S: Microbial metabolites of ingested caffeic acid are absorbed by the monocarboxylic acid transporter (MCT) in intestinal Caco-2 cell monolayers. J Agric Food Chem. 2004 Oct 20;52(21):6418-24. [PubMed:15479001 ]