Record Information |
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Version | 1.0 |
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Created at | 2005-11-16 15:48:42 UTC |
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Updated at | 2021-08-09 22:33:11 UTC |
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NP-MRD ID | NP0000289 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | 4,5-Dihydroorotic acid |
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Description | 4,5-Dihydroorotic acid, also known as dihydroorotate or hydroorotate is a pyrimidinemonocarboxylic acid that results from the base-catalysed cyclisation of N-alpha-carbethoxyasparagine. It is classified as a secondary amide, a monocarboxylic acid, a pyrimidinemonocarboxylic acid and a N-acylurea. 4,5-Dihydroorotic acid is a derivative of orotic acid which serves as an intermediate in pyrimidine biosynthesis. 4,5-Dihydroorotic acid exists in all living species, ranging from bacteria to plants to humans. 4,5-Dihydroorotic acid is synthesized by the enzyme known as Dihydroorotase (EC 3.5.2.3) Which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid as part of the de novo pyrimidine biosynthesis pathway (PMID: 13163076 ). 4,5-Dihydroorotic acid is also a substrate for the enzyme known as dihydroorotate dehydrogenase (DHODH). In mammalian species, DHODH catalyzes the fourth step in the de novo pyrimidine biosynthesis pathway, which involves the ubiquinone-mediated oxidation of dihydroorotate to orotate and the reduction of flavin mononucleotide (FMN) to dihydroflavin mononucleotide (FMNH2). Inhibition of DHODH activity with teriflunomide (an immunomodulatory drug) or expression with RNA interference results in reduced ROS generation and consequent apoptosis of transformed skin and prostate epithelial cells. Mutations in the DHOD gene have been shown to cause Miller syndrome, also known as Genee-Wiedemann syndrome, Wildervanck-Smith syndrome or post-axial acrofacial dystosis (PMID: 19915526 ). |
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Structure | InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11) |
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Synonyms | Value | Source |
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5,6-Dihydro-orotic acid | ChEBI | DL-Dihydroortotic acid | ChEBI | Hydroorotic acid | ChEBI | 5,6-Dihydro-orotate | Generator | DL-Dihydroortotate | Generator | Hydroorotate | Generator | 4,5-Dihydroorotate | Generator | (+)-2,6-Dioxo-hexahydro-pyrimidine-4-carboxylate | HMDB | (+)-2,6-Dioxo-hexahydro-pyrimidine-4-carboxylic acid | HMDB | (R)-2,6-Dioxo-hexahydro-pyrimidine-4-carboxylate | HMDB | (R)-2,6-Dioxo-hexahydro-pyrimidine-4-carboxylic acid | HMDB | (S)-2,6-Dioxo-hexahydro-pyrimidine-4-carboxylate | HMDB | (S)-2,6-Dioxo-hexahydro-pyrimidine-4-carboxylic acid | HMDB | 2,6-Dioxo-hexahydro-pyrimidine-4-carboxylate | HMDB | 2,6-Dioxo-hexahydro-pyrimidine-4-carboxylic acid | HMDB | 5,6-Dihydroorotate | HMDB | L-Hydroorotate | HMDB | L-Hydroorotic acid | HMDB | R,S-Hydroorotate | HMDB | L-Dihydroorotate | HMDB | 4,5-Dihydroorotic acid, (L)-isomer | HMDB | Dihydroorotate | HMDB | 4,5-Dihydroorotic acid, (D)-isomer | HMDB | 4,5-Dihydroorotic acid, (DL)-isomer | HMDB |
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Chemical Formula | C5H6N2O4 |
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Average Mass | 158.1121 Da |
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Monoisotopic Mass | 158.03276 Da |
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IUPAC Name | 2,6-dioxo-1,3-diazinane-4-carboxylic acid |
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Traditional Name | dihydroorotic acid |
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CAS Registry Number | 155-54-4 |
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SMILES | OC(=O)C1CC(=O)NC(=O)N1 |
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InChI Identifier | InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11) |
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InChI Key | UFIVEPVSAGBUSI-UHFFFAOYSA-N |
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Experimental Spectra |
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| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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1D NMR | 1H NMR Spectrum (1D, 500 MHz, H2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 2D NMR | [1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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| Not Available | Species |
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Species of Origin | |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. |
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Kingdom | Organic compounds |
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Super Class | Organic acids and derivatives |
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Class | Carboxylic acids and derivatives |
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Sub Class | Amino acids, peptides, and analogues |
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Direct Parent | Alpha amino acids and derivatives |
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Alternative Parents | |
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Substituents | - Alpha-amino acid or derivatives
- N-acyl urea
- Pyrimidone
- Ureide
- 1,3-diazinane
- Pyrimidine
- Dicarboximide
- Urea
- Carbonic acid derivative
- Azacycle
- Monocarboxylic acid or derivatives
- Carboxylic acid
- Organoheterocyclic compound
- Hydrocarbon derivative
- Organic oxide
- Organooxygen compound
- Organonitrogen compound
- Organopnictogen compound
- Organic oxygen compound
- Carbonyl group
- Organic nitrogen compound
- Aliphatic heteromonocyclic compound
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Molecular Framework | Aliphatic heteromonocyclic compounds |
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External Descriptors | |
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Physical Properties |
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State | Solid |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
- Hagi T, Kobayashi M, Nomura M: Metabolome analysis of milk fermented by gamma-aminobutyric acid-producing Lactococcus lactis. J Dairy Sci. 2016 Feb;99(2):994-1001. doi: 10.3168/jds.2015-9945. Epub 2015 Dec 10. [PubMed:26686724 ]
- LIEBERMAN I, KORNBERG A: Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin. J Biol Chem. 1954 Apr;207(2):911-24. [PubMed:13163076 ]
- Ng SB, Buckingham KJ, Lee C, Bigham AW, Tabor HK, Dent KM, Huff CD, Shannon PT, Jabs EW, Nickerson DA, Shendure J, Bamshad MJ: Exome sequencing identifies the cause of a mendelian disorder. Nat Genet. 2010 Jan;42(1):30-5. doi: 10.1038/ng.499. Epub 2009 Nov 13. [PubMed:19915526 ]
- Suzuki M, Sugano H, Matsumoto K, Yamamura M, Ishida R: Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety. J Med Chem. 1990 Aug;33(8):2130-7. doi: 10.1021/jm00170a014. [PubMed:2115588 ]
- Tsanov V, Tsanov H: Theoretical Analysis of Anticancer Cellular Effects of Glycoside Amides. Anticancer Agents Med Chem. 2021 Sep 3. pii: ACAMC-EPUB-117670. doi: 10.2174/1871520621666210903122831. [PubMed:34477528 ]
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